Endocrine Abstracts

Background: There is evidence that dietary interventions can reduce antibody levels in patients with autoimmune thyroid disease (ATD), which can have a beneficial effect on the clinical manifestations of the disease. The aim of this study was to review the literature regarding the different types of dietary supplementations and their effectiveness in the management of ATDs.Methods: Using a predefined search strategy, four databases were searched (PubMed,...

Background: Primary adrenal insufficiency (PAI) can be associated with significant morbidity in children of all ages, the most common cause being Congenital Adrenal Hyperplasia (CAH). Several other rare inherited causes of PAI have been identified over the years which lack diagnostic phenotypic or biochemical signs, leaving genetic testing as the only approach to make a definitive diagnosis. Our cohort involves >440 patients who presented with features of PAI – hypogl...

Primary adrenal insufficiency (PAI) in children is usually congenital with more than 25 causal genes leading to overlapping phenotypes. A genetic diagnosis is helpful to guide management and genetic counselling but can be challenging in resource limited settings where facilities for antibodies and genetic testing may be unavailable. Studies from Africa are rare but, in Sudan, the most common genetic aetiologies for PAI are congenital adrenal hyperplasia (CAH; mostly CYP21A...